Function of distal convoluted and connecting tubules studied by isolated nephron fragments
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چکیده
منابع مشابه
Alteration in capacity and function of proximal and distal convoluted tubules in kidney exposed by Molybdenum trioxide nanoparticles in female rats (Stereological technique)
Background: One of the applications of molybdenum trioxide nanoparticles (MTNPs) is to use it as an antibacterial agent. The kidney is also one of the most important organs in the body to excrete waste products and regulate many blood factors. Duo to widespread use of MTNPs and the importance of the kidney, the aim of this study was to investigate this drug effect on kidney tubules. Materials ...
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Sodium reabsorption and potassium secretion in the distal convoluted tubule and in the connecting tubule can maintain the homeostasis of the body, especially when dietary sodium intake is high and potassium intake is low. Under these conditions, a large proportion of the aldosterone-regulated sodium and potassium transport would occur in these nephron segments before the tubular fluid reaches t...
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Cl- conductances were studied in cultured rabbit proximal convoluted tubule (PCT) epithelial cells and compared with those measured in cultured distal bright convoluted tubule (DCTb) epithelial cells. Using the whole cell patch-clamp technique, three types of Cl- conductances were identified in DCTb cultured cells. These consisted of volume-sensitive, Ca2+-activated, and forskolin-activated Cl-...
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Tuberous sclerosis complex (TSC) is a multiorgan hamartomatous disease caused by loss of function mutations of either the TSC1 or TSC2 genes. Neurological symptoms of TSC predominate in younger patients, but renal pathologies are a serious aspect of the disease in older children and adults. To study TSC pathogenesis in the kidney, we inactivated the mouse Tsc1 gene in the distal convoluted tubu...
متن کاملA primary culture of distal convoluted tubules expressing functional thiazide-sensitive NaCl transport.
Studying the molecular regulation of the thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC) is important for understanding how the kidney contributes to blood pressure regulation. Until now, a native mammalian cell model to investigate this transporter remained unknown. Our aim here is to establish, for the first time, a primary distal convoluted tubule (DCT) cell culture exhibiting transcellul...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1982
ISSN: 0085-2538
DOI: 10.1038/ki.1982.199